منابع مشابه
A PDZ Switch for a Cellular Stress Response
The accumulation of misfolded porins in the periplasm of bacteria triggers a proteolytic cascade, initiated by activation of DegS, a member of the family of HtrA proteases. Activation of DegS ultimately leads to the expression of genes encoding the periplasmic protein folding machinery. A new study now reveals that binding of exposed C-termini of unassembled porins to the PDZ domain of DegS ind...
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Retrograde axonal transport of cellular signals driven by dynein is vital for neuronal survival. Mouse models with defects in the retrograde transport machinery, including the Loa mouse (point mutation in dynein) and the Tg(dynamitin) mouse (overexpression of dynamitin), exhibit mild neurodegenerative disease. Transport defects have also been observed in more rapidly progressive neurodegenerati...
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Retrograde axonal transport of cellular signals driven by dynein is vital for neuronal survival. Mouse models with defects in the retrograde transport machinery, including the Loa mouse (point mutation in dynein) and the Tg dynamitin mouse (overexpression of dynamitin), exhibit mild neurodegenerative disease. Transport defects have also been observed in more rapidly progressive neurodegeneratio...
متن کاملStructural basis of a protein partner switch that regulates the general stress response of α-proteobacteria.
α-Proteobacteria uniquely integrate features of two-component signal transduction (TCS) and alternative sigma factor (σ) regulation to control transcription in response to general stress. The core of this regulatory system is the PhyR protein, which contains a σ-like (SL) domain and a TCS receiver domain. Aspartyl phosphorylation of the PhyR receiver in response to stress signals promotes bindi...
متن کاملStress response in cyanobacteria
Cyanobacteria are an important source of natural products. In this article, we briefly review the responses of cyanobacteria to different stresses. Abiotic stresses (temperature, salt, heavy metals, metalloid and ultraviolet (UV) influence cell growth and metabolism in cyanobacteria. Salt stress is a major abiotic factor that decrease...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2007
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2093